Det anerkendte engelske tidsskrift The British Journal of Psychiatry har publiceret en artikel om PANDAS, der understøtter teorien.
I Danmark er behandlingen af OCD, herunder PANDAS desværre meget mangelfuld eller helt ikke-eksisterende. Sundhedsministerien mener dog det modsatte.
Background Obsessions and compulsions may occur in the post-streptococcal disorders Sydenham’s chorea and paediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS). The proposed mediators are anti-basal ganglia antibodies (ABGA).
Aims We tested the hypothesis that post-streptococcal autoimmunity may have a role in‘idiopathic’obsessive–compulsive disorder (OCD).
Method We examined 50 children with OCD for ABGA using enzyme-linked immunosorbent assay (ELISA) and western immunoblotting. The findings were compared with paediatric autoimmune (n=50), neurological (n=100) and streptococcal (n=40) controls.
Results The mean ABGA binding on ABGA binding on ELISA was elevated in the patient cohort compared with all control groups (P<0.005 in all comparisons). Western immunoblotting revealed positive antibody binding (as seen in Sydenham’s chorea) in 42% of the patient cohort compared with 2–10% of control groups (P<0.001 in all comparisons).
Conclusions Our findings support the hypothesis that central nervous system autoimmunity may have a role in a significant subgroup of cases of OCD. Further studyis required to examine whether the antibodies concerned are pathogenic.
Source: The British Journal of Psychiatry (2005) 187: 314-319, Incidence of anti-brain antibodies in children with obsessive–compulsive disorder
Updated 1st october:
BBC News 30 september 2005, Anxiety disorder ‘infection link’
Some cases of obsessive compulsive disorder in children may be a result of an immune reaction following an infection, scientists believe.
Researchers found children with OCD were more likely to have antibodies associated with streptococcal infection than those without the disorder.
But the joint Institute of Psychiatry and Institute of Neurology team said more research was needed.
The findings were reported in the British Journal of Psychiatry.
About 3% of the population suffers from the anxiety disorder, which is generally treated by drugs or cognitive behaviour therapy counselling.
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